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M. Francis GIRAUD

Contact details

Phone
+33473407127
Email
Francis.GIRAUD@uca.fr

Activities / Resume

Francis Giraud graduated in 2004 from the Ecole Nationale Supérieure de Chimie de Mulhouse as chemical engineer. The same year, he obtained his master degree from the Haute Alsace University under the supervision of Prof. Jacques Eustache and Pierre van de Weghe. In 2007 he received his PhD in organic chemistry from the Nantes Atlantique University (France) under the supervision of Pr. Marc Le Borgne and Dr. Cédric Logé for his work on the design and synthesis of indole derivatives with potential antifungal or antileishmanial interest. After a one-year post-doc in the same group with Prof. Muriel Duflos and Pascal Marchand, he reached Dr. René Grée’s group in Rennes (France) to work on the preparation of fluorinated analogues of melatonin. In 2009, he obtained a temporary position as research and teaching assistant in the group of Prof. Pascale Moreau at the Blaise Pascal University (Clermont-Ferrand, France). In 2010, he was appointed Assistant Professor the same group and obtained his "Habilitation à Diriger des Recherches" in 2017. His research interests are mainly dealing with the development of original synthetic routes of aza-heterocyclic compounds as potential kinases inhibitors.

Additional informations

Publications HAL de Francis,GIRAUD de la collection PRES_CLERMONT

2021

titre
Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors
auteur
Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
article
Molecules, MDPI, 2021, 26 (9), pp.2696. ⟨10.3390/molecules26092696⟩
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Journal articles
DOI
DOI : 10.3390/molecules26092696
Accès au texte intégral et bibtex
https://hal.uca.fr/hal-03219644/file/molecules-26-02696-v3.pdf BibTex
titre
Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia
auteur
Alexia Visseq, Amélie Descheemaeker, Karine Hérault, Francis Giraud, Isabelle Abrunhosa-Thomas, Alain Artola, Fabrice Anizon, Radhouane Dallel, Pascale Moreau
article
European Journal of Medicinal Chemistry, Elsevier, 2021, 225, pp.113748. ⟨10.1016/j.ejmech.2021.113748⟩
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Journal articles
DOI
DOI : 10.1016/j.ejmech.2021.113748
Accès au texte intégral et bibtex
https://hal.archives-ouvertes.fr/hal-03334145/file/EurJMedChem-2021-113748.pdf BibTex

2020

titre
Synthesis and kinase inhibitory potencies of new pyrido[3,4-g]quinazolines substituted at the 8-position
auteur
Yannick Esvan, Béatrice Josselin, Blandine Baratte, Stéphane Bach, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau
article
ARKIVOC - Online Journal of Organic Chemistry, Arkat USA Inc, 2020, 2020 (7), pp.105-116. ⟨10.24820/ark.5550190.p011.268⟩
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DOI
DOI : 10.24820/ark.5550190.p011.268
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titre
Synthesis and biological activities of new pyrrolocarbazole-imidazobenzimidazole conjugates
auteur
Fabrice Anizon, Francis Giraud, Ekaterina Ivanova, Dmitry Kaluzhny, Alexander Shtil, Federico Cisnetti, Pascale Moreau
article
Tetrahedron Letters, Elsevier, 2020, 61 (30), pp.152096. ⟨10.1016/j.tetlet.2020.152096⟩
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Journal articles
DOI
DOI : 10.1016/j.tetlet.2020.152096
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https://hal.archives-ouvertes.fr/hal-02901961/file/S0040403920305475.pdf BibTex
titre
Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia
auteur
Alexia Visseq, Amélie Descheemaeker, Nicolas Pinto-Pardo, Lionel Nauton, Vincent Thery, Francis Giraud, Isabelle Abrunhosa-Thomas, Alain Artola, Fabrice Anizon, Radhouane Dallel, Pascale Moreau
article
European Journal of Medicinal Chemistry, Elsevier, 2020, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩
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Journal articles
DOI
DOI : 10.1016/j.ejmech.2019.111917
Accès au texte intégral et bibtex
https://hal.archives-ouvertes.fr/hal-02444268/file/S0223523419310694.pdf BibTex

2019

titre
Synthesis and Applications of Dihydropyrrolocarbazoles
auteur
Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
article
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (31-32), pp.5025-5042. ⟨10.1002/ejoc.201900269⟩
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DOI
DOI : 10.1002/ejoc.201900269
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titre
A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia
auteur
Ronja Bjørnstad, Reidun Aesoy, Øystein Bruserud, Annette K. Brenner, Francis Giraud, Tara Helen Dowling, Gro Gausdal, Pascale Moreau, Stein Ove Døskeland, Fabrice Anizon, Lars Herfindal
article
Molecular Cancer Therapeutics, American Association for Cancer Research, 2019, 18 (3), pp.567-578. ⟨10.1158/1535-7163.MCT-17-1234⟩
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DOI
DOI : 10.1158/1535-7163.MCT-17-1234
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2018

titre
Synthesis and antiproliferative evaluation of glucosylated pyrazole analogs of K252c
auteur
Bachir Douara, Yannick Esvan, Elisabeth Pereira, Francis Giraud, Yulia Volodina, Dmitry Kaluzhny, Alexander Shtil, Fabrice Anizon, Pascale Moreau
article
Tetrahedron, Elsevier, 2018, 74 (8), pp.892 - 901. ⟨10.1016/j.tet.2018.01.017⟩
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DOI
DOI : 10.1016/j.tet.2018.01.017
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2016

titre
Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.
auteur
Pascale Moreau, Fabrice Anizon, Francis Giraud, Yannick J Esvan
article
Recent Patents on Anti-Cancer Drug Discovery, Bentham Science Publishers, 2016, 11, pp.309-321. ⟨10.2174/1574892811666160519141628⟩
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DOI
DOI : 10.2174/1574892811666160519141628
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titre
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure.
auteur
Yannick J. Esvan, Wael Zeinyeh, Thibaut Boibessot, Lionel Nauton, Vincent Théry, Stefan Knapp, Apirat Chaikuad, Nadège Loaëc, Laurent Meijer, Fabrice Anizon, Francis Giraud, Pascale Moreau
article
European Journal of Medicinal Chemistry, Elsevier, 2016, 118, pp.170-177. ⟨10.1016/j.ejmech.2016.04.004⟩
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Journal articles
DOI
DOI : 10.1016/j.ejmech.2016.04.004
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titre
Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.
auteur
Wael Zeinyeh, Yannick J. Esvan, Lionel Nauton, Nadège Loaëc, Laurent Meijer, Vincent Théry, Fabrice Anizon, Francis Giraud, Pascale Moreau
article
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26, pp.4327-4329. ⟨10.1016/j.bmcl.2016.07.032⟩
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DOI
DOI : 10.1016/j.bmcl.2016.07.032
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titre
Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.
auteur
Yannick J. Esvan, Francis Giraud, Elisabeth Pereira, Virginie Suchaud, Lionel Nauton, Vincent Théry, Lyubov G. Dezhenkova, Dmitry N. Kaluzhny, Vsevolod N. Mazov, Alexander A. Shtil, Fabrice Anizon, Pascale Moreau
article
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24, pp.3116-3124. ⟨10.1016/j.bmc.2016.05.032⟩
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DOI
DOI : 10.1016/j.bmc.2016.05.032
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2015

titre
Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells.
auteur
Francis Giraud, Marion Bourhis, Edris Ebrahimi, Lars Herfindal, Romy Roy Choudhury, Ronja Bjørnstad, Stein Ove Døskeland, Fabrice Anizon, Pascale Moreau
article
Bioorganic and Medicinal Chemistry, Elsevier, 2015, 23, pp.7313-7323. ⟨10.1016/j.bmc.2015.10.031⟩
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DOI
DOI : 10.1016/j.bmc.2015.10.031
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2014

titre
New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities.
auteur
Francis Giraud, Marion Bourhis, Lionel Nauton, Vincent Théry, Lars Herfindal, Stein Ove Døskeland, Fabrice Anizon, Pascale Moreau
article
Bioorganic Chemistry, Elsevier, 2014, 57, pp.108-115. ⟨10.1016/j.bioorg.2014.09.004⟩
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DOI
DOI : 10.1016/j.bioorg.2014.09.004
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titre
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition
auteur
Virginie Suchaud, Laurent Gavara, Francis Giraud, Lionel Nauton, Vincent Théry, Fabrice Anizon, Pascale Moreau
article
Bioorganic and Medicinal Chemistry, Elsevier, 2014, 22, pp.4704-4710. ⟨10.1016/j.bmc.2014.07.011⟩
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DOI
DOI : 10.1016/j.bmc.2014.07.011
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2012

titre
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.
auteur
Francis Giraud, Rufine Akué-Gédu, Lionel Nauton, Nicolas Candelon, Eric Debiton, Vincent Théry, Fabrice Anizon, Pascale Moreau
article
European Journal of Medicinal Chemistry, Elsevier, 2012, 56, pp.225-236
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2011

titre
Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives
auteur
Pascale Moreau, Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Georges Alves, Eric Debiton, Lionel Nauton, Vincent Thery, Olivier Lozach, Laurent Meijer
article
17th European Symposium on Organic Chemistry, Jul 2011, Hersonissos, Greece
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Conference papers
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titre
Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives.
auteur
Francis Giraud, Georges Alves, Eric Debiton, Lionel Nauton, Vincent Thery, Emilie Durieu, Yoan Ferandin, Olivier Lozach, Laurent Meijer, Fabrice Anizon, Elisabeth Pereira, Pascale Moreau
article
Journal of Medicinal Chemistry, American Chemical Society, 2011, 54, pp.4474-4489
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