M. Francis GIRAUD

Contact details

Phone: +33473407127
Email: Francis.GIRAUD@uca.fr

Activities / Resume

Francis Giraud graduated in 2004 from the Ecole Nationale Supérieure de Chimie de Mulhouse as chemical engineer. The same year, he obtained his master degree from the Haute Alsace University under the supervision of Prof. Jacques Eustache and Pierre van de Weghe. In 2007 he received his PhD in organic chemistry from the Nantes Atlantique University (France) under the supervision of Pr. Marc Le Borgne and Dr. Cédric Logé for his work on the design and synthesis of indole derivatives with potential antifungal or antileishmanial interest. After a one-year post-doc in the same group with Prof. Muriel Duflos and Pascal Marchand, he reached Dr. René Grée’s group in Rennes (France) to work on the preparation of fluorinated analogues of melatonin. In 2009, he obtained a temporary position as research and teaching assistant in the group of Prof. Pascale Moreau at the Blaise Pascal University (Clermont-Ferrand, France). In 2010, he was appointed Assistant Professor the same group and obtained his "Habilitation à Diriger des Recherches" in 2017. His research interests are mainly dealing with the development of original synthetic routes of aza-heterocyclic compounds as potential kinases inhibitors.

Additional information

Publications HAL de Francis,GIRAUD de la collection PRES_CLERMONT

2025

titre: Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells
auteur: Ingeborg Nerbø Reiten, Francis Giraud, Tuva Torblå Augedal, Jan-Lukas Førde, Pascale Moreau, Edvin Tang Gundersen, David Chapron, François-Xavier Legrand, Fabrice Anizon, Lars Herfindal
article: International Journal of Pharmaceutics, 2025, 668, pp.124989. ⟨10.1016/j.ijpharm.2024.124989⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ijpharm.2024.124989
Accès au bibtex

2024

titre: Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells
auteur: Ingeborg Nerbø Reiten, Francis Giraud, Tuva Torblå Augedal, Jan-Lukas Førde, Pascale Moreau, Edvin Tang Gundersen, David Chapron, François-Xavier Legrand, Fabrice Anizon, Lars Herfindal
article: International Journal of Pharmaceutics, 2024, pp.124989. ⟨10.1016/j.ijpharm.2024.124989⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ijpharm.2024.124989
Accès au bibtex

titre: Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one
auteur: Théo Frazier, Pauline Murail, Francis Giraud, Alain Artola, Radhouane Dallel, Fabrice Anizon, Pascale Moreau
article: Synthesis: Journal of Synthetic Organic Chemistry, 2024, 56 (13), pp.2093-2099. ⟨10.1055/s-0043-1763758⟩
typdoc: Journal articles
DOI: DOI : 10.1055/s-0043-1763758
Accès au bibtex

titre: The Nitro Group Reshapes the Effects of Pyrido[3,4-g]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells
auteur: Sophia Borisevich, Tatiana Aksinina, Margarita Ilyina, Victoria Shender, Ksenia Anufrieva, Georgij Arapidi, Nadezhda Antipova, Fabrice Anizon, Yannick Esvan, Francis Giraud, Victor Tatarskiy, Pascale Moreau, Mikhail Shakhparonov, Marat Pavlyukov, Alexander Shtil
article: Cancers, 2024, 16 (4), pp.834. ⟨10.3390/cancers16040834⟩
typdoc: Journal articles
DOI: DOI : 10.3390/cancers16040834
Accès au bibtex

titre: Synthesis of diversely substituted pyridin-2(1 H )-ones and in vivo evaluation of their anti-allodynic effect on cutaneous inflammatory mechanical allodynia
auteur: Théo Frazier, Pauline Murail, Arthur Boulangé, Nazim Chalane, Francis Giraud, Alain Artola, Radhouane Dallel, Fabrice Anizon, Pascale Moreau
article: RSC Medicinal Chemistry, 2024, 15 (8), pp.2900-2921. ⟨10.1039/d4md00375f⟩
typdoc: Journal articles
DOI: DOI : 10.1039/d4md00375f
Accès au bibtex

titre: Synthesis of diversely substituted pyridin-2(1H)-ones and in vivo evaluation of their anti-allodynic effect on cutaneous inflammatory mechanical allodynia
auteur: Théo Frazier, Pauline Murail, Arthur Boulangé, Nazim Chalane, Francis Giraud, Alain Artola, Radhouane Dallel, Fabrice Anizon, Pascale Moreau
article: RSC Medicinal Chemistry, 2024, 15 (8), pp.2900-2921. ⟨10.1039/d4md00375f⟩
typdoc: Journal articles
DOI: DOI : 10.1039/d4md00375f
Accès au texte intégral et bibtex

titre: Synthesis and biological evaluation of 1H-pyrrolo[3,2–g]isoquinolines
auteur: Mathilde Defois, Béatrice Josselin, Pierre Brindeau, Andreas Krämer, Stefan Knapp, Fabrice Anizon, Francis Giraud, Sandrine Ruchaud, Pascale Moreau
article: Bioorganic and Medicinal Chemistry, 2024, 100, pp.117619. ⟨10.1016/j.bmc.2024.117619⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmc.2024.117619
Accès au texte intégral et bibtex

titre: Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one
auteur: Théo Frazier, Pauline Murail, Francis Giraud, Alain Artola, Radhouane Dallel, Fabrice Anizon, Pascale Moreau
article: Synthesis: Journal of Synthetic Organic Chemistry, 2024, 56 (13), pp.2093-2099. ⟨10.1055/s-0043-1763758⟩
typdoc: Journal articles
DOI: DOI : 10.1055/s-0043-1763758
Accès au texte intégral et bibtex

titre: Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles
auteur: Théo Frazier, Elisabeth Pereira, Reidun Aesoy, Lionel Nauton, Francis Giraud, Lars Herfindal, Fabrice Anizon, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2024, 269, pp.116352. ⟨10.1016/j.ejmech.2024.116352⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2024.116352
Accès au texte intégral et bibtex

2023

titre: Synthesis of (2-aminopyrimidin-4-yl)(pyridin-4-yl)methanone and derivatives
auteur: Francis Giraud, Béatrice Josselin, Sandrine Ruchaud, Fabrice Anizon, Pascale Moreau
article: Synthesis: Journal of Synthetic Organic Chemistry, 2023, 55 (22), pp.3825-3832. ⟨10.1055/a-2107-4571⟩
typdoc: Journal articles
DOI: DOI : 10.1055/a-2107-4571
Accès au texte intégral et bibtex

2022

titre: Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells
auteur: Tatyana Larionova, Soniya Bastola, Tatiana Aksinina, Ksenia Anufrieva, Jia Wang, Victoria Shender, Dmitriy Andreev, Tatiana Kovalenko, Georgij Arapidi, Polina Shnaider, Anastasia Kazakova, Yaroslav Latyshev, Victor Tatarskiy, Alexander Shtil, Pascale Moreau, Francis Giraud, Chaoxi Li, Yichan Wang, Maria Rubtsova, Olga Dontsova, Michael Condro, Benjamin Ellingson, Mikhail Shakhparonov, Harley Kornblum, Ichiro Nakano, Marat Pavlyukov
article: Nature Cell Biology, 2022, 24 (10), pp.1541-1557. ⟨10.1038/s41556-022-00994-w⟩
typdoc: Journal articles
DOI: DOI : 10.1038/s41556-022-00994-w
Accès au bibtex

titre: Synthesis of new pyrazolo[4,3-a]phenanthridine Pim-1 inhibitors and evaluation of their cytotoxic activity towards the MOLM-13 acute myeloid leukemia cell line
auteur: Etienne Auvert, Reidun Aesoy, Francis Giraud, Lars Herfindal, Fabrice Anizon, Pascale Moreau
article: Bioorganic and Medicinal Chemistry Letters, 2022, 73, pp.128914. ⟨10.1016/j.bmcl.2022.128914⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmcl.2022.128914
Accès au texte intégral et bibtex

titre: Synthesis and biological evaluation of Haspin inhibitors: kinase inhibitory potency and cellular activity
auteur: Wael Zeinyeh, Yannick Esvan, Béatrice Josselin, Mathilde Defois, Blandine Baratte, Stefan Knapp, Apirat Chaikuad, Fabrice Anizon, Francis Giraud, Sandrine Ruchaud, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2022, 236, pp.114369. ⟨10.1016/j.ejmech.2022.114369⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2022.114369
Accès au texte intégral et bibtex

titre: Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines
auteur: Mathilde Defois, Chloé Rémondin, Béatrice Josselin, Lionel Nauton, Vincent Théry, Fabrice Anizon, Sandrine Ruchaud, Francis Giraud, Pascale Moreau
article: Molecules, 2022, 27 (17), pp.5578. ⟨10.3390/molecules27175578⟩
typdoc: Journal articles
DOI: DOI : 10.3390/molecules27175578
Accès au texte intégral et bibtex

2021

titre: Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors
auteur: Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
article: Molecules, 2021, 26 (9), pp.2696. ⟨10.3390/molecules26092696⟩
typdoc: Journal articles
DOI: DOI : 10.3390/molecules26092696
Accès au texte intégral et bibtex

titre: Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia
auteur: Alexia Visseq, Amélie Descheemaeker, Karine Hérault, Francis Giraud, Isabelle Abrunhosa-Thomas, Alain Artola, Fabrice Anizon, Radhouane Dallel, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2021, 225, pp.113748. ⟨10.1016/j.ejmech.2021.113748⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2021.113748
Accès au texte intégral et bibtex

2020

titre: Synthesis and kinase inhibitory potencies of new pyrido[3,4-g]quinazolines substituted at the 8-position
auteur: Yannick Esvan, Béatrice Josselin, Blandine Baratte, Stéphane Bach, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau
article: ARKIVOC - Online Journal of Organic Chemistry, 2020, 2020 (7), pp.105-116. ⟨10.24820/ark.5550190.p011.268⟩
typdoc: Journal articles
DOI: DOI : 10.24820/ark.5550190.p011.268
Accès au bibtex

titre: Synthesis and biological activities of new pyrrolocarbazole-imidazobenzimidazole conjugates
auteur: Fabrice Anizon, Francis Giraud, Ekaterina Ivanova, Dmitry Kaluzhny, Alexander Shtil, Federico Cisnetti, Pascale Moreau
article: Tetrahedron Letters, 2020, 61 (30), pp.152096. ⟨10.1016/j.tetlet.2020.152096⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.tetlet.2020.152096
Accès au texte intégral et bibtex

titre: Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia
auteur: Alexia Visseq, Amélie Descheemaeker, Nicolas Pinto-Pardo, Lionel Nauton, Vincent Thery, Francis Giraud, Isabelle Abrunhosa-Thomas, Alain Artola, Fabrice Anizon, Radhouane Dallel, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2020, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2019.111917
Accès au texte intégral et bibtex

2019

titre: Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia
auteur: Alexia Visseq, Amélie Descheemaeker, Nicolas Pinto-Pardo, Lionel Nauton, Vincent Théry, Francis Giraud, Isabelle Abrunhosa-Thomas, Alain Artola, Fabrice Anizon, Radhouane Dallel, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2019, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2019.111917
Accès au bibtex

titre: Synthesis and Applications of Dihydropyrrolocarbazoles
auteur: Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
article: European Journal of Organic Chemistry, 2019, 2019 (31-32), pp.5025-5042. ⟨10.1002/ejoc.201900269⟩
typdoc: Journal articles
DOI: DOI : 10.1002/ejoc.201900269
Accès au bibtex

titre: Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies
auteur: Waël Zeinyeh, Yannick Esvan, Béatrice Josselin, Blandine Baratte, Stéphane Bach, Lionel Nauton, Vincent Thery, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau
article: Bioorganic and Medicinal Chemistry, 2019, 27 (10), pp.2083-2089. ⟨10.1016/j.bmc.2019.04.005⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmc.2019.04.005
Accès au texte intégral et bibtex

titre: New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis
auteur: Helmi Tazarki, Wael Zeinyeh, Yannick J. Esvan, Stefan Knapp, Deep Chatterjee, Martin Schröder, Andreas C. Joerger, Jameleddine Khiari, Béatrice Josselin, Blandine Baratte, Stéphane Bach, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2019, 166, pp.304-317. ⟨10.1016/j.ejmech.2019.01.052⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2019.01.052
Accès au texte intégral et bibtex

titre: A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia
auteur: Ronja Bjørnstad, Reidun Aesoy, Øystein Bruserud, Annette K. Brenner, Francis Giraud, Tara Helen Dowling, Gro Gausdal, Pascale Moreau, Stein Ove Døskeland, Fabrice Anizon, Lars Herfindal
article: Molecular Cancer Therapeutics, 2019, 18 (3), pp.567-578. ⟨10.1158/1535-7163.MCT-17-1234⟩
typdoc: Journal articles
DOI: DOI : 10.1158/1535-7163.MCT-17-1234
Accès au bibtex

2018

titre: Synthesis and antiproliferative evaluation of glucosylated pyrazole analogs of K252c
auteur: Bachir Douara, Yannick Esvan, Elisabeth Pereira, Francis Giraud, Yulia Volodina, Dmitry Kaluzhny, Alexander Shtil, Fabrice Anizon, Pascale Moreau
article: Tetrahedron, 2018, 74 (8), pp.892 - 901. ⟨10.1016/j.tet.2018.01.017⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.tet.2018.01.017
Accès au bibtex

2016

titre: Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure.
auteur: Yannick J. Esvan, Wael Zeinyeh, Thibaut Boibessot, Lionel Nauton, Vincent Théry, Stefan Knapp, Apirat Chaikuad, Nadège Loaëc, Laurent Meijer, Fabrice Anizon, Francis Giraud, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2016, 118, pp.170-177. ⟨10.1016/j.ejmech.2016.04.004⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ejmech.2016.04.004
Accès au texte intégral et bibtex

titre: Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.
auteur: Pascale Moreau, Fabrice Anizon, Francis Giraud, Yannick J Esvan
article: Recent Patents on Anti-Cancer Drug Discovery, 2016, 11, pp.309-321. ⟨10.2174/1574892811666160519141628⟩
typdoc: Journal articles
DOI: DOI : 10.2174/1574892811666160519141628
Accès au bibtex

titre: Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.
auteur: Wael Zeinyeh, Yannick J. Esvan, Lionel Nauton, Nadège Loaëc, Laurent Meijer, Vincent Théry, Fabrice Anizon, Francis Giraud, Pascale Moreau
article: Bioorganic and Medicinal Chemistry Letters, 2016, 26, pp.4327-4329. ⟨10.1016/j.bmcl.2016.07.032⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmcl.2016.07.032
Accès au bibtex

titre: Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.
auteur: Yannick J. Esvan, Francis Giraud, Elisabeth Pereira, Virginie Suchaud, Lionel Nauton, Vincent Théry, Lyubov G. Dezhenkova, Dmitry N. Kaluzhny, Vsevolod N. Mazov, Alexander A. Shtil, Fabrice Anizon, Pascale Moreau
article: Bioorganic and Medicinal Chemistry, 2016, 24, pp.3116-3124. ⟨10.1016/j.bmc.2016.05.032⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmc.2016.05.032
Accès au bibtex

2015

titre: Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells.
auteur: Francis Giraud, Marion Bourhis, Edris Ebrahimi, Lars Herfindal, Romy Roy Choudhury, Ronja Bjørnstad, Stein Ove Døskeland, Fabrice Anizon, Pascale Moreau
article: Bioorganic and Medicinal Chemistry, 2015, 23, pp.7313-7323. ⟨10.1016/j.bmc.2015.10.031⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmc.2015.10.031
Accès au bibtex

2014

titre: Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition
auteur: Virginie Suchaud, Laurent Gavara, Francis Giraud, Lionel Nauton, Vincent Théry, Fabrice Anizon, Pascale Moreau
article: Bioorganic and Medicinal Chemistry, 2014, 22, pp.4704-4710. ⟨10.1016/j.bmc.2014.07.011⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bmc.2014.07.011
Accès au bibtex

titre: New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities.
auteur: Francis Giraud, Marion Bourhis, Lionel Nauton, Vincent Théry, Lars Herfindal, Stein Ove Døskeland, Fabrice Anizon, Pascale Moreau
article: Bioorganic Chemistry, 2014, 57, pp.108-115. ⟨10.1016/j.bioorg.2014.09.004⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.bioorg.2014.09.004
Accès au bibtex

2012

titre: Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.
auteur: Francis Giraud, Rufine Akué-Gédu, Lionel Nauton, Nicolas Candelon, Eric Debiton, Vincent Théry, Fabrice Anizon, Pascale Moreau
article: European Journal of Medicinal Chemistry, 2012, 56, pp.225-236
typdoc: Journal articles
Accès au bibtex

2011

titre: Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives
auteur: Pascale Moreau, Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Georges Alves, Eric Debiton, Lionel Nauton, Vincent Thery, Olivier Lozach, Laurent Meijer
article: 17th European Symposium on Organic Chemistry, Jul 2011, Hersonissos, Greece
typdoc: Conference papers
Accès au bibtex

titre: Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives.
auteur: Francis Giraud, Georges Alves, Eric Debiton, Lionel Nauton, Vincent Thery, Emilie Durieu, Yoan Ferandin, Olivier Lozach, Laurent Meijer, Fabrice Anizon, Elisabeth Pereira, Pascale Moreau
article: Journal of Medicinal Chemistry, 2011, 54, pp.4474-4489
typdoc: Journal articles
Accès au bibtex

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M. Francis GIRAUD

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M. Francis GIRAUD

Contact details

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